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M9480549.TXT
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1994-08-20
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Document 0549
DOCN M9480549
TI A new look at HIV transmission from seropositive mothers to their
infants: the facts beyond serology.
DT 9410
AU Jehuda-Cohen T; Pediatric Research Unit, Rappaport Faculty of Medicine,;
Technion-Israel Institute of Technology, Haifa, Israel.
SO Isr J Med Sci. 1994 May-Jun;30(5-6):364-8. Unique Identifier : AIDSLINE
MED/94307914
AB Once the curtain of maternal antibodies is removed (12-18 months) only a
fraction of the infants are seropositive. Some babies from whom virus
has been isolated or detected in their cells subsequently become
seronegative. What does the negative serology of these children really
tell us about exposure to HIV? It is suggested that seroconverting is
only one of the ways to respond to an HIV exposure from an infected
mother; it is not the only or the best way. Some form of tolerance to
HIV, emerging after in utero exposure of the fetus, could theoretically
lead to a seronegative state despite infection. Based on monkey studies
with simian immunodeficiency virus (SIV), this tolerance could offer
protection against pathological outcome of the infection. Seronegative
yet infected/exposed children of HIV-positive mothers exist, though
their number remains unknown. They might hold the key to a protective
immunity to HIV.
DE Animal Cercocebus atys Female Human HIV Antibodies/IMMUNOLOGY HIV
Infections/EPIDEMIOLOGY/*TRANSMISSION HIV Seropositivity/*IMMUNOLOGY
Infant Infant, Newborn Israel/EPIDEMIOLOGY Macaca mulatta Pregnancy
Simian Acquired Immunodeficiency Syndrome/IMMUNOLOGY/TRANSMISSION
JOURNAL ARTICLE REVIEW REVIEW, ACADEMIC
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).